Human Papillomavirus (HPV) infections rank among the most prevalent sexually transmitted diseases, affecting around 80% of both men and women over their lifetimes. HPV primarily targets cutaneous and mucosal epithelia. While most cases result in asymptomatic infections cleared by the immune system within 1-2 years, persistent infections can escalate to HPV-associated cancers, notably affecting the cervix, anal canal, penis, vulva, vagina, and the upper aerodigestive tract.

Interestingly, HPV has also been linked to an increased B-cell lymphoma incidence. Moreover, some studies have shown evidence of HPV infection in B-cell lymphoma cells, suggesting that HPV- driven oncogenic effects might directly contribute to B-cell transformation. Despite these intriguing findings, the specific mechanisms linking HPV to B-cell lymphomagenesis remain elusive. This project aims to shed light on these mechanisms, providing a clearer understanding of the intricate association between HPV and B-cell lymphoma development. Through targeted research, we aspire to unravel specific HPV-driven mechanisms in B-cell lymphoma, offering valuable insights for improved treatment and prevention strategies for this disease.