Welcome to the Leukemia and Immuno-Oncology lab. The main focus of our lab is to explore the molecular mechanisms driving leukemia and lymphoma, and to develop novel therapeutic strategies specifically designed for these malignancies. In addition, our interest extends also to the study of autoimmune disorders, for which we aim to design and implement new targeted cell-based therapies.
Towards these goals, we use a broad range of experimental strategies that comprises basic molecular biology and biochemical methods, and bioinformatic analyses, as well as the use of in vitro and in vivo preclinical models, and experimental therapeutics techniques. These approaches allow us not only to address critical questions about the origin and progression of the diseases that we study but also to identify new therapeutic strategies for their treatment.
Our laboratory is structured on three main pillars, each dedicated to the study of a specific disease: Juvenile Myelomonocytic Leukemia (JMML), B-cell lymphoma, and Systemic Lupus Erythematosus (SLE). Aligned with this distribution, we have defined the following research goals:
To explore the oncogenic mechanisms driving JMML and develop new targeted therapies
To define the role of Human Papilloma Virus (HPV) infection in B-cell lymphoma generation and progression
To develop new cell-based therapeutic strategies for SLE
We are confident that our results will have an important impact on the diagnosis and treatment of these diseases and expand the therapeutic options available to the patients. Moreover, our close collaboration with clinical teams in the development of this project will guarantee that our most promising discoveries have a rapid and direct impact in the clinic.